Opportunity Information: Apply for PAR 22 078
The Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional), Funding Opportunity Number PAR 22-078, is a National Institutes of Health (NIH) grant program designed to accelerate the careers of early-stage, independent clinical researchers by giving them a structured path to build and sustain an impactful research program. The core idea is to create a deliberate bridge between NIH's intramural research environment (research conducted within NIH) and the broader extramural community (research conducted at universities, hospitals, and other external institutions). By combining a substantial initial period embedded at NIH with a later transition option to an outside institution, the program is set up to help promising clinician-scientists establish independence, develop leadership experience, and produce research outputs that can support long-term career stability.
The program is organized into two sequential phases. In the first phase, selected Lasker Scholars receive a tenure-track-style appointment within the NIH Intramural Research Program for up to 5 to 7 years. During this time, scholars operate as independent investigators with their own research budgets, which is a major feature of the program because it supports genuine scientific independence rather than a purely mentored fellowship experience. This intramural phase is meant to provide access to NIH's clinical research infrastructure, specialized resources, and a dense collaborative environment that can be particularly valuable for human-subjects research, translational studies, and other clinically oriented work.
In the second phase, scholars who successfully complete the intramural period can receive up to 3 additional years of NIH support to continue their research at an extramural research facility, such as an academic medical center or research institute. This second-phase support is intended to help the investigator transition their program, personnel, and momentum to an external setting without the typical funding gap that can occur during major career moves. Alternatively, the scholar may be considered to remain as an investigator within the NIH intramural program rather than transitioning outside, which preserves flexibility based on the investigator's trajectory and NIH's needs. The "Clinical Trial Optional" designation indicates that applications may propose clinical trials where appropriate, but a clinical trial is not required to be responsive.
Eligibility is broad across U.S.-based organizations and includes many common domestic applicant categories such as state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; certain tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than higher education institutions); for-profit organizations other than small businesses; and small businesses. The announcement also explicitly highlights additional eligible applicant types that align with NIH's interest in engaging a wide range of institutions and communities, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, the FOA clearly restricts foreign participation: non-domestic (non-U.S.) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as NIH defines them in the NIH Grants Policy Statement) are not allowed.
From an administrative standpoint, this is a discretionary grant opportunity under NIH, with the funding instrument listed as a grant and an activity category spanning areas such as education, environment, food and nutrition, and health. The FOA is associated with multiple CFDA numbers (including 93.113, 93.121, 93.173, 93.213, 93.233, 93.279, 93.398, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.866, and 93.879), reflecting that the program can align with a wide range of NIH institutes and mission areas depending on the scholar's proposed clinical research focus. The opportunity was created on January 26, 2022, and the original closing date listed is June 24, 2022. The publicly provided excerpt does not specify an award ceiling or the expected number of awards, which typically means applicants should rely on the full FOA details and NIH guidance for budget expectations and cohort size.
Overall, the Lasker Clinical Research Scholars Program stands out because it is not just a single grant award but a career-structuring mechanism that combines protected time, independence, and a built-in transition option. It is aimed at clinicians and clinically focused investigators who are ready to run an independent research program and who would benefit from the NIH intramural setting as a launchpad, followed by either continued intramural investigation or a supported move to an extramural institution where the work can expand and mature.Apply for PAR 22 078
- The National Institutes of Health in the education, environment, food and nutrition, health sector is offering a public funding opportunity titled "Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.233, 93.279, 93.398, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.866, 93.879.
- This funding opportunity was created on 2022-01-26.
- Applicants must submit their applications by 2022-06-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional)?
The Lasker Clinical Research Scholars Program is an NIH grant program designed to accelerate the careers of early-stage, independent clinical researchers. It provides a structured path to build and sustain an impactful clinical research program by combining an initial period within the NIH Intramural Research Program and an optional later transition to an extramural (non-NIH) institution with continued NIH support.
What is the Funding Opportunity Number (FON) for this program?
The Funding Opportunity Number is PAR 22-078.
What does the program mean by "intramural" and "extramural" research?
"Intramural" research refers to research conducted within NIH. "Extramural" research refers to research conducted outside NIH at universities, hospitals, academic medical centers, research institutes, and other eligible external organizations.
What is the main goal of this program?
The program is intended to help promising clinician-scientists establish independence, gain leadership experience, and generate research outputs that support long-term career stability. A central feature is creating a deliberate bridge from the NIH intramural environment to the broader extramural community (or allowing continued work intramurally, depending on the scholar's trajectory and NIH needs).
How is the program structured?
The program has two sequential phases: (1) an intramural phase at NIH for up to 5 to 7 years and (2) a possible extramural phase with up to 3 additional years of NIH support for researchers who transition to an outside institution. The program also allows the possibility that a scholar remains within the NIH intramural program rather than transitioning outside.
How long is the intramural phase?
The intramural phase provides a tenure-track-style appointment within the NIH Intramural Research Program for up to 5 to 7 years.
What is the scholar's role during the intramural phase?
During the intramural period, scholars operate as independent investigators and have their own research budgets. This is positioned as a key feature because it supports genuine independence rather than functioning as a purely mentored fellowship.
Why does the program emphasize the NIH intramural environment?
The intramural phase is meant to provide access to NIH clinical research infrastructure, specialized resources, and a highly collaborative environment. This can be especially valuable for clinically oriented work such as human-subjects research and translational studies.
What happens after the intramural phase ends?
Scholars who successfully complete the intramural period may receive up to 3 additional years of NIH support to continue their research at an extramural research facility (for example, an academic medical center or research institute). Alternatively, the scholar may be considered to remain as an investigator in the NIH intramural program.
How long is the extramural transition support?
The extramural phase can provide up to 3 additional years of NIH support.
What is the purpose of the second (extramural) phase?
The second-phase support is intended to help scholars transition their research program, personnel, and momentum to an external setting without the typical funding gap that can happen during major career moves.
Does a scholar have to transition to an extramural institution?
No. The information provided indicates there is flexibility: scholars may transition to an extramural setting with support, or they may be considered to remain within the NIH intramural program.
What does "Clinical Trial Optional" mean for this opportunity?
"Clinical Trial Optional" means an application may propose a clinical trial where appropriate, but proposing a clinical trial is not required for the application to be considered responsive.
What types of organizations are eligible to apply?
Eligibility includes a broad range of U.S.-based organizations, including state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; certain tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than higher education institutions); for-profit organizations other than small businesses; and small businesses.
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The announcement explicitly highlights additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are not eligible to apply.
Can a U.S. organization include a non-U.S. component in the application?
No. The FOA states that non-domestic components of U.S. organizations are not eligible, and foreign components (as NIH defines them in the NIH Grants Policy Statement) are not allowed.
What is the funding instrument for this opportunity?
The funding instrument is listed as a grant, and the opportunity is described as a discretionary grant opportunity under NIH.
What activity categories does this opportunity span?
The activity category spans areas such as education, environment, food and nutrition, and health.
Why are there multiple CFDA numbers associated with this program?
The program is associated with multiple CFDA numbers, reflecting that it can align with a wide range of NIH institutes and mission areas depending on the scholar's proposed clinical research focus.
Which CFDA numbers are associated with this opportunity (from the provided excerpt)?
The excerpt lists CFDA numbers 93.113, 93.121, 93.173, 93.213, 93.233, 93.279, 93.398, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.866, and 93.879.
When was this opportunity created?
The opportunity was created on January 26, 2022.
What is the closing date listed in the provided information?
The original closing date listed is June 24, 2022.
Does the provided excerpt specify an award ceiling or the expected number of awards?
No. The excerpt does not specify an award ceiling or the expected number of awards.
What should applicants do if they need budget expectations or information about cohort size?
Because the excerpt does not provide an award ceiling or expected number of awards, applicants are directed (by implication in the provided text) to rely on the full FOA details and NIH guidance for budget expectations and cohort size.
How is this program different from a typical single research grant?
The program is described as more than a single grant award. It functions as a career-structuring mechanism that combines protected time, independence, and a built-in transition option from the NIH intramural setting to an extramural institution (or continued intramural work).
Who is this program primarily aimed at?
It is aimed at clinicians and clinically focused investigators who are ready to run an independent research program and who would benefit from the NIH intramural setting as a launchpad, followed by either continued intramural investigation or a supported move to an extramural institution.
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