Behavioral and Integrative Treatment Development Program (R34 Clinical Trial Optional) | PAR 24 300

Opportunity Information: Apply for PAR 24 300

The Behavioral and Integrative Treatment Development Program (R34 Clinical Trial Optional), funding opportunity number PAR-24-300, is a National Institutes of Health (NIH) discretionary grant designed to support early, focused research that develops and refines behavioral interventions related to substance use and addiction. The central aim is to move promising behavioral approaches toward stronger evidence by testing efficacy and, when appropriate, conducting clinical trials. This FOA is especially geared toward intervention development work that goes beyond simply asking whether something works; it also emphasizes understanding how and why an intervention works, what "dose" or intensity is needed to produce benefit, and how to optimize treatment components so programs are more effective and scalable in real-world settings.

A major theme of the program is integrative and strategic treatment design. NIH is seeking studies that help determine the best sequencing and combination of interventions, including behavioral approaches used alone, paired with medications, delivered sequentially, or integrated into a coordinated model. This includes drug abuse treatment interventions for people with co-occurring conditions (comorbidities), recognizing that many patients receiving substance use treatment also face mental health disorders, medical complications, or social and structural barriers that affect outcomes. The FOA also highlights treatment adherence as a key research focus, supporting projects that improve engagement, retention, and consistent participation in drug abuse treatment and related care.

Technology-enabled interventions are explicitly encouraged, particularly when technology can strengthen outcomes while also making programs easier to implement and sustain. That can include digital tools that increase adherence, extend support outside clinic visits, improve monitoring and feedback, or reduce burden on staff while maintaining fidelity to an evidence-based protocol. The opportunity also prioritizes research that addresses HIV prevention within drug abuse treatment settings, specifically interventions that reduce HIV acquisition or transmission risk among individuals in treatment. In addition, it supports work aimed at improving adherence not only to substance use treatment, but also to HIV medications and addiction medications, reflecting the reality that medication adherence is often a decisive factor in long-term outcomes.

Another highlighted area is the intersection of substance misuse and chronic pain. The FOA welcomes intervention development research that treats substance misuse in the context of chronic pain, which often requires carefully balanced approaches that address pain management, functioning, and risk of misuse simultaneously. Across all these topics, the announcement notes that research of interest includes, but is not limited to, Stage I research, indicating an emphasis on early-stage behavioral treatment development activities such as refining intervention components, testing feasibility and acceptability, and generating preliminary signals of efficacy and mechanism before larger-scale trials.

The grant mechanism is R34, with clinical trials listed as optional, meaning applicants can propose projects that include a clinical trial component when it is justified by the development stage and research questions, but the mechanism also accommodates intervention development work that may not require a full clinical trial design. The program sits within NIH health and education activity areas and is associated with CFDA numbers 93.273 and 93.279.

Eligibility is broad and includes many types of U.S. organizations and government entities. Eligible applicants include state, county, city or township governments, special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, and a range of nonprofit organizations (both with and without 501(c)(3) status). For-profit organizations (other than small businesses) and small businesses are also eligible, along with public housing authorities and Indian housing authorities. Tribal eligibility includes federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized governments. The FOA also calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, eligible federal government agencies, and even non-U.S. entities (foreign organizations), signaling an intent to support diverse institutional contexts and communities.

Key administrative details from the listing include an original closing date of 2025-05-07 and a creation date of 2025-01-22. An award ceiling is not specified in the provided source data, and the expected number of awards is also not listed here. Overall, the opportunity is best suited for teams developing practical, mechanism-informed behavioral or integrated interventions for substance use treatment, adherence, HIV-related risk reduction in treatment populations, and substance misuse with chronic pain, with a clear pathway toward optimized, implementable, and sustainable treatment strategies.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Behavioral and Integrative Treatment Development Program (R34 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.279.
• This funding opportunity was created on 2025-01-22.
• Applicants must submit their applications by 2025-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 24 300

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